个人介绍
韩胜,2015年至2019年于复旦大学化学系攻读博士学位,导师陈芬儿院士。2020年3月至2022年6月,在中国科学院上海药物研究所开展博士后研究工作,合作导师为胡有洪研究员。2022年12月加入上海大学医学院。主要从事抗病毒以及炎症相关药物的研究,发表SCI论文多篇,其中IF >5 的5篇,封面论文1篇;申请发明专利4项,1项已授权;主持国家自然科学基金青年科学基金项目和中国博士后科学基金项目。
主要研究领域
1. 小分子抗病毒药物的研发(包括HIV逆转录酶、埃博拉EBOV-GP以及新冠病毒主蛋白酶等靶点相关抑制剂的研究);
2. 海洋生物功能分子的发现及其抗炎活性。
代表性学术成果
论文
1. S. Han, Y. Lei, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors, Chin. Chem. Lett. 2020, 31, 764–768. (IF= 8.455)
2. S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, Fragment hopping-based discovery of novel sulfinylacetamide- diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors, Eur. J. Med. Chem. 2020, 185, 111874-111886. (IF= 7.088)
3. S. Han, H. Li, W. Chen, L. Yang, X. Tong, J. Zuo, and Y. Hu, Discovery of Potent Ebola Entry Inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide Scaffold, Eur. J. Med. Chem. 2022, 240, 114608-114619. (IF= 7.088)
4. S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles, ACS. Infect. Dis. 2020, 6, 787-801. (封面论文, IF= 5.578)
5. Z. Deng, S. Han (共一), M. Ke, Y. Ning, F.E. Chen, Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters, Chem Commun, 2022, 58, 3921-3924. (IF= 6.065)
6. Y. Lei, S. Han (共一), C. Pannecouque, E. De Clercq, C. Zhuang, F. Chen, Design of biphenyl‐substituted diarylpyrimidines with a cyanomethyl linker as HIV‐1 NNRTIs via a molecular hybridization strategy, Molecules. 2020, 25, 1050-1064. (IF= 4.927)
7. W. Chen, B. Feng, S. Han (共一), P. Wang, W. Chen, Y. Zang, J. Li, Y. Hu, Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold, Bioorg. Med. Chem. Lett., 2022, 58, 128526-128531. (IF= 2.94)