个人介绍

王娟，2021年毕业于复旦大学药学院，获得博士学位，同年入职上海大学医学院任讲师。代表性论文发表在Cell Death & Disease、Acta Pharmacologica Sinica、Signal Transduction and Targeted Therapy、Journal of Medicinal Chemistry等期刊上。已授权中国发明专利两项。主持一项国家自然科学基金青年项目，一项上海大学青年英才起航计划和一项上海高校青年教师培养资助计划。

主要研究领域

1. 皮肤的发育、损伤修复、衰老与纤维化；

2. 皮肤相关疾病发生发展的机制探索；

3. 毛发发生、发育的机理研究；

4. 分子靶向药物筛选及机制探索。

代表性学术成果

论文

1. Wang J, Zhang Y, Huang WJ, Yang J, Tang WG, Huang TM, Tan W. ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic. Acta Pharmacologica Sinica. 2021

2. Yang J#, Wang J#, Liu Y, Zhang Y, et al. PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation. Cell death & Disease. 2021

3. Wang J, Ding XL. IL-17 signaling in skin repair: safeguarding metabolic adaptation of wound epithelial cells. Signal Transduction and Targeted Therapy.2022

4. Wang J#, Cui BP#, Chen ZJ, Ding XL. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling. Frontiers in Cell and Developmental Biology.2022

5. Wang J, Eming SA*, Ding XL*. Role of mTOR Signaling Cascade in Epidermal Morphogenesis and Skin Barrier Formation. Biology.2022

6. Huang WJ, Li H, Tan WF*, Wang J*. ABT-737 suppresses aberrant Hedgehog pathway and overcomes resistance to smoothened antagonists by blocking Gli. Medical Oncology. 2022

7. Liu G#, Huang W#, Wang J#, Liu X, Yang J, Zhang Y, et al. Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription. J Med Chem. 2017