个人介绍

谢雨洁，副教授，上海市海外高层次人才。本科和硕士毕业于兰州大学化学系(导师：唐瑜教授)。2016年于英国华威大学高分子化学专业开展博士的研究工作（导师：Rachel O’Reilly）。2020年至2021年在英国伯明翰大学进行博士后的研究工作。于2022年1月加入上海大学医学院，承担上海市海外高层次领军人才项目、国家自然科学基金青年基金、国家科技部外专项目等。目前共发表文章50余篇，以第一作者/通讯作者（含共同）身份在国际著名期刊发表SCI论文30余篇，包括国际主流学术期刊J. Am. Chem. Soc., Adv. Mater., Nat. Commun., Angew. Chem. Int. Ed, Cell Reports Medicine, Chem. Soc. Rev., Adv. Sci., Adv. Funct. Mater., Macromolecules.等。另外以合作者身份在Nat. Chem.、J. Am. Chem. Soc.、Nat. Commun.、Adv. Mater.、Angew. Chem. Int. Ed、Chem. Sci.等期刊发表论文20余篇，申请国家发明专利8项。担任Adv. Mater., Angew. Chem. Int. Ed., Chem, Adv. Funct. Mater, Small, ACS Appl. Mater. Interfaces等期刊独立审稿人。

主要研究领域

1、高分子基的智能药物载体设计、肿瘤纳米疫苗开发；2、二维、三维高分子基生物医用材料。

招生信息：我们课题组目前依托陈雨老师生物医用材料团队，主要致力于高分子基生物医用材料的开发，研究方向涵盖智能药物载体、免疫调控制剂、功能性水凝胶以及微针材料等。近年来，组内多名同学凭借出色的科研表现先后荣获国家奖学金，并在“挑战杯”等国家级科创竞赛中取得了优异成绩。我们始终秉持开放交流的理念，诚挚欢迎各位同学前来参观指导、探讨合作！

代表性学术成果

第一作者/通讯作者论文（最具代表性2023-2025）

[1] Ye Wu, Wencong Jia, Tianlai Xia, Jing Liao, Wenjin He, Huijing Wang, Wei Yang, Xinyue Dai, Wei Feng, Rachel K. O’Reilly, Zaizai Tong*, Meihua Yu*, Yujie Xie*, Yu Chen*, NIR-Actuated Morphodynamic 2D Nanopatches for Interface-Programmed Immunoactivation and Tumor Regression, J. Am. Chem. Soc. 2026, 148, 3, 2902–2919

[2] Wencong Jia, Wei Yang, Ye Wu, Hongze Ren, Yiwen Jia, Weifan Ye, Yujie Xie*, Yu Chen*, Meihua Yu*, Sono-Destructive Polymeric Nanocapsules Enable Spatiotemporal Orchestration of DC-T Cell Crosstalk in Combined In Situ Vaccination and Cytokine Therapy, J. Am. Chem. Soc. 2025, 147, 29, 25553–25570

[3] Huijing Wang, Wenjin He, Jing Liao, Shuangshuang Wang, Xinyue Dai, Meihua Yu*, Yujie Xie*, Yu Chen*, Catalytic Biomaterials-Activated In Situ Chemical Reactions: Strategic Modulation and Enhanced Disease Treatment. Adv. Mater. 2025, 37, 2411967.

[4] Wencong Jia, Ye Wu, Yujie Xie*, Meihua Yu*, Yu Chen*, Advanced Polymeric Nanoparticles for Cancer Immunotherapy: Materials Engineering, Immunotherapeutic Mechanism and Clinical Translation. Adv. Mater. 2025, 2413603.

[5] Yujie Xie, Zaizai Tong, Tianlai Xia, Joshua C. Worch, Julia Y. Rho, Rachel K. O’Reilly*, Andrew P. Dove*, 2D Hierarchical Microbarcodes with Expanded Storage Capacity for Optical Multiplex and Information Encryption, Adv. Mater. 2024, 36, 2308154.

[6] Jake E. Barker, Joshua D. Tibbetts, Calum T. J. Ferguson, Yujie Xie*, Rachel K. O'Reilly*, Substituted Maleimides: Self-Reportable Linkers and Tags in Bioconjugation, Materials Science, and Nanotechnology Angew. Chem. Int. Ed. 2024, e202410550.

[7] Xinyue Dai, Yujie Xie*, Wei Feng*, Yu Chen*, Nanomedicine-enabled chemical regulation of reactive X species for versatile disease treatments, Angew. Chem.Int. Ed.. 2023, e202309160

[8] Yujie Xie, Maria C. Arno, Jonathan T. Husband, Miquel Torrent-Sucarrat, Rachel K. O’Reilly* Manipulating the Fluorescence Lifetime at The Sub-cellular Scale via Photo-switchable Barcoding. Nat. Commun. 2020, 11, 2460 Editor’s Highlight

[9] Sun, Guangjie, Guangjie Sun, Yize Dong, Ying Wang, Yihong Su, Jiajun Chen,∙Jiali Deng, Lan Luo, Xinyue Cao, Weiping Lu, Kai Chen, Meihua Yu*, Yujie Xie*, Bingcang Huang*, Yu Chen*, Cell Reports Medicine, 102640, DOI: 10.1016/j.xcrm.2026.102640

[10] Ran Tao, Huijing Wang, Ruijie Hou, Bowen Zheng, Yidan Zhao, Yujie Xie*, Zaizai Tong*, Program the “Light-Flashable” 2D Fluorescent Lifetime Microbarcodes for Precision Information Storage, Adv. Funct. Mater. 2025, 2500737

[11] Hongze Ren, Anqi Zhu, Wei Yang, Yiwen Jia, Hui Cheng, Ye Wu, Zhengqi Tang, Weifan Ye, Mayu Sun, Yujie Xie*, Meihua Yu*, Yu Chen*, 2D Differential Metallic Immunopotentiators Drive High Diversity and Capability of Antigen-specific Immunity Against Tumor. Adv. Sci. 2024, 2405729

[12] Anqi Zhu, Hongze Ren, Xiaolong Li, Wei Yang, Xiaoxia Han, Xiaodong Hou, Shen Zhang, Shaoyue Li, Yujie Xie*, Meihua Yu*, Yu Chen*, Huixiong Xu*, Transdermal STING nano-agonists enhance multifaced functions of antigen-specific T cells triggered by sonodynamic cancer vaccination. Nanotoday. 2025, 61, 102590

[13] Meng Chen, Lili Xia, Chenyao Wu, Zeyu Wang, Li Ding*, Yujie Xie*, Wei Feng*, Yu Chen* Microbe-material hybrids for therapeutic applications Chem. Soc. Rev., 2024, 53, 8306

[14] Hongze Ren, Wencong Jia, Yujie Xie*, Meihua Yu*, Yu Chen*, Adjuvant physiochemistry and advanced nanotechnology for vaccine development, Chem. Soc. Rev., 2023, 52, 5172-5254

[15] Kexing Li, Shuangshuang Wang, Chunmei Chen, Yujie Xie*, Xinyue Dai*, Yu Chen*, Sonocatalytic biomaterials, Coord. Chem. Rev., 522, 216242

[16] Yujie Xie, Wei Yu, Tianlai Xia, Rachel K. O’Reilly * Andrew P. Dove*, Stereocomplex-driven morphological transition (SDMT) of coil-rod-coil poly(lactic acid)-based cylindrical nanoparticles, Macromolecules, 2023, 56, 19, 7689-7697.

[17] Bingbing Xiang, Xiang Wang, Feiyang Teng, Liping Liu, Meili Li, Xiancheng Meng, Zhenyan Chu, Xianjing Zhou*, Yujie Xie* Zaizai Tong*, Regulation of Two-Dimensional Platelet Micelles by Dynamic Changing of Polymer Topological Architectures upon Light Irradiation, Macromolecules, 2023, 56, 9685-9696

[18] Sang Guangze, Wang Bingkai*, Yujie Xie*, Chen Yu*, Yang Feng*, Engineered Probiotic-Based Biomaterials for Inflammatory Bowel Disease Treatment. Theranostics 2025; 15(8):3289-3315.

[19] Xu Zhang, Guanhao Chen, Bowen Zheng, Zhengwei Wan, Liping Liu, Lingyuan Zhu, Yujie Xie*, and Zaizai Tong*, Uniform two-dimensional crystalline platelets with tailored compositions for pH stimulus-responsive drug release, Biomacromolecules 2023, 24, 1032-1041