个人介绍

      杨剑，2017年博士毕业于中国药科大学药物化学专业，2015年到2017年作为联合培养博士在哈佛医学院/麻省总院进行研究工作，2017年7月到2020年7月在中国药科大学从事博士后工作，主要研究方向是化学生物学及分子影像学。发表SCI论文16篇，包括Proc. Natl. Acad. Sci. USA, Chem Sci., Chem. Comm., Mol Imaging Biol.等杂志，申请国际专利1项，国内专利1项。多次应邀参加国内外学术会议并做会议报告，担任《Analytical Chemistry》、《Scientific Reports》等杂志的审稿人。主持国家自然科学基金面上项目1项，中国博士后基金1项，参与国家自然科学基金青年基金1项。

主要研究领域

1. 开发可用于老年痴呆早期诊断的分子影像技术

2. 针对老年痴呆中氧化应激的研究

代表性学术成果

论文

1. Jian Yang#, Xueli Zhang#, Peng Yuan#, Jing Yang, Yungen Xu, Jaime Grutzendler, Yihan Shao, Anna Moore, Chongzhao Ran. Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease. Proceedings of the National Academy of Sciences, 2017, 114 (47): 12384-12389. (IF=9.58)

2. Jian Yang#, Fantian Zeng#, Xiaofang Li, Chongzhao Ran, Yungen Xu, Yuyan Li. Highly Specific Detection of Aβ Oligomers in Early Alzheimer’s Disease by Near-infrared Fluorescent Probe with a “V-shaped” Spatial Conformation. Chemical Communications, 2020, 56, 583-586. (IF=6.164)

3. Jian Yang#, Ran Cheng#, Hualong Fu, Jing Yang, Jie Lu, Yengen Xu, Steven H. Liang, Mengchao Cui, Chongzhao Ran. Half-curcuminoid analogues as PET imaging probes for Amyloid beta species. Chemical Communications, 2019. 55(25):3630-3633. (IF=6.164)

4. Yuyan Li#, Jian Yang# (co-first author), Hongwu Liu, Jing Yang, Lei Du, Haiwei Feng, Yanli Tian, Jianqin Cao, Chongzhao Ran. Tuning the Stereo-hindrance of Curcumin Scaffold for the Selective Imaging of the Soluble Forms of Amyloid Beta Species. Chemical Science, 2017, 8(11): 7710–7717. (IF=9.556)

5. Jing Yang#, Jian Yang# (co-first author), JianPing Xiong, Chunhua Qiao, Chongzhao Ran. Auto-economical design of PET tracer for imaging αvβ3 integrin via utilizing three-in-one function of 64CuCl2. Chemical Communications, 2020, 56 (12), 1788-1791. (IF=6.164)

社会学术兼职

《Analytical Chemistry》、《Scientific Reports》等SCI杂志的审稿人。