个人介绍:
王娟，副研究员。2021年毕业于复旦大学药学院，获得博士学位，同年入职上海大学医学院。代表性论文发表在 Signal Transduction and Targeted Therapy, Cell Death & Disease, J Nanobiotechnology, Journal of Medicinal Chemistry等期刊上。已授权中国发明专利8项。主持国家自然科学基金青年项目，国家科技部外国专家项目等。
主要研究领域:
分子靶向药物筛选及作用机制研究；
皮肤发育及修复新靶点、新机制研究;
细胞外囊泡在皮肤疾病中的作用及机制研究。
近5年最具代表性论文:
1. Juan Wang*, Xiaojie Li*, Xinyue Zhao, et al. Lactobacillus rhamnosus GG-derived Extracellular Vesicles Promote Wound Healing via miR-21-5p-mediated Re-epithelization and Angiogenesis. J Nanobiotechnology. 2024.
2. Juan Wang*#, Yanyan Zhang*, Siqi Yuan*, et al. Gut probiotic Akkermansia muciniphila-derived Extracellular Vesicles Deliver miR-21-5p to Alleviate Atopic Dermatitis by Targeting TLR4 Signaling. Nano research. 2026.
3. Juan Wang*, Siqi Yuan*, Xiuwen Zhang, et al. Ultrasound-Triggered Dissolving Microneedle Platform for cGAS-STING-Mediated Precision Immunotherapy of Melanoma. Materials Today Bio. 2026.
4. Hanyu Dou, Jianzhou Li, Lin Lin, Mengyu Jin, Jingyuan Wang, Hequn Fu, Jiongming Lu, Qinyi Chen, Leihong Xiang#, Juan Wang#, Xiaolei Ding#. 4E-BP1 acts as a molecular rheostat balancing regenerative healing and fibrotic scarring. Experimental & Molecular Medicine.2026.
5. Yanyan Zhang*, Yuanjie Zhu*, Mengyu Jin, Jing Chen, Siqi Yuan, Minjia Yuan, Yuou Sha, Qingmei Liu, Wenyu Wu#, Juan Wang#, Xiaolei Ding. Rutin Stabilizes β-catenin through GSK3β Inhibition to Promote Hair Follicle Regeneration. Cell Proliferation. 2026.
6. Juan Wang, Xiaolei Ding. IL-17 Signaling in Skin Repair: Safeguarding Metabolic Adaptation of Wound Epithelial Cells. Signal Transduct Target Ther. 2022.
7. Juan Wang, Yu Zhang, WenJing Huang, et al. ABT-199 Inhibits Hedgehog Pathway by Acting as a Competitive Inhibitor of Oxysterol, Rather as a BH3 mimetic. Acta Pharmacol Sin. 2021.
8. Juan Wang, Siqi Yuan, Zhi Lu, et al, Extracellular Vesicles in Skin Health, Siseases, and Aging. Interdisciplinary Medicine. 2024.
9. Jun Yang*, Juan Wang*, et al. PGE2-JNK Signaling Axis Non-canonically Promotes Gli Activation by Protecting Gli2 from Ubiquitin-proteasomal Degradation. Cell Death Dis. 2021.
社会学术兼职:
Exploration青年编委
Journal of Dermatopharmacy青年编委
皮肤药理专业委员会青年委员
