个人介绍：
田宇，副研究员，硕士生导师。本科和硕士毕业于中国药科大学，药剂学专业；博士毕业于荷兰格罗宁根大学（导师：Henderik W. Frijlink），药剂学专业。2023年11月加入上海大学医学院。主持国家自然科学基金面上项目、青年项目，上海市自然科学基金，上海市科委扬帆计划，国家科技部外专项目，上海市高校青年教师培养资助计划等7个项目。以第一作者/通讯作者（含共同）在Adv. Funct. Mater., J. Control. Release, Chem. Eng. J., Carbohydr. Polym., Asian J. Pharm. Sci. 等国际权威期刊发表SCI论文20余篇。申请发明专利2项，授权专利1项。担任上海市药学会药剂学专委会青年委员、世界中医药学会联合会经皮给药专委会会员、Exploration 期刊青年编委，Nano Research、Int. J. Pharm、 Eur J Pharm Biopharm 等杂志独立审稿人。
主要研究领域：
1. 智能微针经皮递送系统：设计智能响应型纳米载药系统，并与智能控件及微针给药技术相结合，构建可实现精准调控与可控释放的智能微针经皮给药系统。
2. 抗肿瘤药物纳米递送系统联合肿瘤免疫治疗：基于肿瘤微环境的生理学特征，构建环境响应型抗肿瘤药物纳米递送系统，并与肿瘤免疫治疗策略相结合，以实现协同增效的抗肿瘤治疗效果。
3. 蛋白/多肽类药物及疫苗递送系统研究：通过引入新型稳定化策略，将蛋白、多肽类药物及疫苗与递送载体相结合，构建高效递送系统，以提升其理化稳定性、生物利用度及体内免疫应答效果。
代表性学术成果：
论文（最具代表性）
[1] Y. Tian, L. Xia, X. Song, Yu Chen. Dissolving microneedles as in situ chemical reaction chambers: from design strategies to versatile biomedical applications. Adv. Funct. Mater. 2025; 35, 2422274. IF=19.0
[2] Y. Tian, B. Chang, Z. Zong, J. Wang, X. Lu, Y. Li, Q. Zheng, R. Wei, Y. Shen, Y. Chen. Guanidine grafted chitosan oligosaccharides polymers promoting GLUT-mediated gastrointestinal barrier transport for potentiating Fe3O4 mineralized probiotics in obesity treatment. Carbohydr. Polym. 2025; 366, 123918. IF=12.5
[3] X. Gu, J. Liu, H. Xiang, R. Liao, Y. Ge, D. Damdinjav, B. Dorjsuren, T. Hao, D. Chen, Y. Tian*, Y. Shen*. Fixed-point cleaved bioinspired nanosystem via promoting LAT1-mediated BBB penetration for spatiotemporal therapy in TMZ resistant glioblastoma. Chem. Eng. J. 2025; 517, 164470. IF=13.2
[4] Y. Tian, H. Jing, Q. Wang, et al. Dissolving microneedles-based programmed delivery system for enhanced chemo-immunotherapy of melanoma. J Control Release. 023; 360:630-646. IF=11.5
[5] X. Lin, H. Xiang, J. Wu, R. Liao, Y. Li, B. Xu, Y. Xu, Y. Shen, Q. Li, Y. Tian*. The Evolution ofLipid Nanoparticles: Pavingthe Way for Next-Generation Nucleic Acid Medicines. Asian J. Pharm. Sci. 2025 (Accepted). IF=11.9
[6] F Cheng, Y Tian*, Y Chen. Pancatalytic tumor therapy by ultrasound activation of inorganic sonosensitizers. ChemBioChem. e202500440. IF=2.8
[7] Q. Wang#, Y. Tian#, L. Liu#, C. Chen, et al. Precise targeting therapy of orthotopic gastric carcinoma by siRNA and chemotherapeutic drug codelivered in pH‐sensitive nano platform. Adv Healthc Mater. 2021; 10:2100966. IF= 10.0
[8] Y. Tian, G. Mi, Q. Chen, et al. Acid-induced activated cell-penetrating peptide-modified cholesterol-conjugated polyoxyethylene sorbitol oleate mixed micelles for pH-triggered drug release and efficient brain tumor targeting based on a charge reversal mechanism. ACS Appl Mater Interfaces.2018; 10: 43411-43428. IF= 8.2
[9] Y. Tian, J. Lee, K van der Maaden, et al. Intradermal administration of influenza vaccine with trehalose and pullulan-based dissolving microneedle arrays. J Pharm Sci. 2022; 111:1070-1080. IF=3.8
[10] Y. Tian, Y.C. Bhide, H.J. Woerdenbag, et al. Development of an orodispersible film containing stabilized influenza vaccine. Pharmaceutics. 2020; 12:245. IF= 5.5
[11] Y. Tian, M. Orlu, H.J. Woerdenbag, et al. Oromucosal films: from patient centricity to production by printing techniques. Expert Opin Drug Deliv. 2019; 16: 981-993.2019; 16: 981-993. IF= 5.4
[12] Y. Tian, J.C. Visser, J.S. Klever, et al. Orodispersible films based on blends of trehalose and pullulan for protein delivery. Eur J Pharm Biopharm. 2018; 133: 104-111. IF= 4.3
[13] Y. Tian, Y. Shen, M. Jv. Synthesis, characterization and evaluation of tinidazole-loaded mPEG-PDLLA (10/90) in situ gel forming system for periodontitis treatment. Drug Deliv. 2016; 23(8):2726-2735. IF=8.1
科研项目
1. 国家自然科学基金，面上项目，82573949, 2026.01-20029.12, 在研，主持
2. 国家自然科学基金，青年项目，82102906, 2022.01-2024.12，结题，主持
3. 上海市自然科学基金，25ZR1402163，2025.07-2028.06，在研，主持
4. “一带一路”创新人才交流外国专家项目，H20250873，2025.01-2026.12，在研，主持
5. 上海市 “科技创新行动计划”扬帆计划项目，21YF1444800，2021.05-2024.04，结题，主持
6. 上海市高校青年教师培养资助计划，2025-2026，主持
7. 上海大学，上海大学启航计划，N.13-G210-24-378，2024.04至2025.04，在研，主持
