个人介绍

王美艳，上海大学研究员，2010年博士毕业于复旦大学。目前主要从事合成生物学和智能化生物材料在再生医学、肿瘤治疗等领域的研究。其研究成果已经发表在PNAS、Nature Communications、Science Advances、ACS nano、Advanced Science等国际学术期刊。申请专利10项，其中授权专利5项。获得国家自然科学基金面上项目2项，上海市自然科学基金面上项目1项，重庆市自然科学基金面上项目1项，中央高校基本科研业务费学科交叉类项目1项并以学术骨干参与“干细胞及转化研究”重点专项1项、国家重点基础研究发展计划（973计划）3项、国家自然科学基金国际合作项目1项、上海市科委基础处合成生物学重大专项1项和上海自然基金1项。

主要研究领域

合成生物学与再生医学，智能化生物材料用于肿瘤精准治疗

代表性学术成果

论文（最具代表性）

1.Xin Wu #, Yuanhuan Yu #, Meiyan Wang #, Di Dai, Jianli Yin, Wenjing Liu, Deqiang Kong, Shasha Tang, Meiyao Meng, Tian Gao, Yuanjin Zhang, Yang Zhou, Ningzi Guan, Shangang Zhao, Haifeng Ye. AAV-delivered muscone-induced transgene system for treating chronic diseases in mice via inhalation. Nature Communications, 2024 ,15(1):1122.

2.Fengjuan Xie, Shasha Tang, Ye Zhang, Yinbing Zhao, Yingying Lin, Yining Yao, Meiyan Wang*, Zhengying Gu*, Jingjing Wan*. Designing peptide-based nanoinhibitors of programmed cell death ligand 1 (PD-L1) for enhanced chemo-immunotherapy. ACS Nano, 2024,18(2):1690-1701.

3.Meiyan Wang#, Yuanxiao Liu#, Ziwei Wang, Longliang Qiao, Xiaoding Ma, Lingfeng Hu, Deqiang Kong^,, Yuan Wang and Haifeng Ye*.An optogenetic-controlled cell reprogramming system for driving cell fate and light-responsive chimeric mice. Advanced Science, 2023, e2202858.

4.Yuanhuan Yu#, Xin Wu#, Meiyan Wang#, Wenjing Liu, Li Zhang, Ying Zhang, Zhilin Hu, Wenzheng Jiang, Qiang Zou, Fengfeng Cai* and Haifeng Ye*. Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy. Nature Communications,2022, 13(1): 6357.

5.Xinyi Wang, Kaili Dong, Deqiang Kong, Yang Zhou, Jianli Yin, Fengfeng Cai, Meiyan Wang*, Haifeng Ye*. A far-red light-inducible CRISPR-Cas12a platform for remote-controlled genome editing and gene activation. Science Advances, 2021,7(50): eabh2358.

6.Jiali Wu#, Meiyan Wang#, Xueping Yang#, Chengwei Yi, Jian Jiang, Yuanhuan Yu，Haifeng Ye*. A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice. Nature Communications, 2020,11(1):3708.

7.Jiawei Shao#, Meiyan Wang#, Guiling Yu#, Sucheng Zhu, Yuanhuan Yu, Boon Chin Heng, Jiali Wu, Haifeng Ye*. Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Proc Natl Acad Sci USA, 2018, 115 (29): E6722-E6730.

8.Meiyan Wang, Xiaomei Yang,Peng Zhang,Lei Cai, Xibin Yang, Youwei Chen, Yuanya Jing , Jilie Kong, Xiaowei Yang,* and Fang-Lin Sun* .Sustained delivering growth factors with polyethyleneimine modified nanoparticles promotes embryonic stem cells differentiation and liver regeneration. Advanced Science, 2016, 3(8): 1500393. (Highlighted by MaterialsViews China)

参编著作

Meiyan Wang, Jiali Wu, and Haifeng Ye. Opsin-free Optogenetics: Technology and Applications. Chapter 10 Constructing a Far-Red Light-Induced Split-Cre Recombinase System for Controllable Genome Engineering.

教学方面

1.指导2024届本科生获得第八届全国大学生生命科学竞赛（2023，科学探究类）三等奖，第五届上海市大学生生命科学竞赛二等奖

2.指导2023届本科生获得第七届全国大学生生命科学竞赛（2022，科学探究类）二等奖，第四届上海市大学生生命科学竞赛一等奖。

3.指导2022届本科生参加了创新创业训练培育项目，获得第六届全国大学生生命科学竞赛（2021，科学探究类）三等奖，第三届上海市大学生生命科学竞赛二等奖。