个人介绍：

王惠芳，副研究员，硕士生导师。博士毕业于浙江大学化学工程与技术专业，长期从事肿瘤靶向治疗、生物药物、细胞疗法及递送系统研究，聚焦肿瘤免疫调控与靶向蛋白降解等前沿干预策略。目前主持国家自然科学基金、广东省区域联合基金及中国博士后科学基金各1项。以第一作者在 Cell Reports Medicine、Nature Communications、Science Advances、Advanced science、Biomaterials 等国际高水平期刊发表SCI论文10余篇，获授权国家发明专利5项。

主要研究领域：

1. 肿瘤靶向治疗（ADC、细胞治疗、工程菌）

2. 靶向蛋白调控

3. 纳米递送系统

代表性学术成果：

论文（最具代表性）

(1) H. Wang^#, L. Zheng^#, C. Yang^#, L. Jia^#, R. Zhou, H. Liu, Y. Dong, X. Xu, G. Shi, J. Yang, Y. Li, H. Yuan, J. Cen, G. Zhang, L. Yu, T. Guo, H. Jiang, Y. Liu, X. Wang*, Z. Li*, J. Wang*. Probiotic-Mediated Tumor Microenvironment Reprogramming with Protease-Sensitive Interleukin-15 and Photothermal Therapy. Cell Reports Medicine, 2025, 6(6).

(2) R. Zhou#, H. Wang#, G. Zhang#, Y. Liu, X. Liu, Z. Li, G. Shi, J. Yuan, C. Qu, Y. Li, L. Chen, J. Huang, H. Zhou, L. Dai, C. Bai, J. Wang, L. Yu, Z. Li*, Y. Li*. Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression. Nature Communications, 2025, 16:9374.

(3) H. Wang^#, R. Zhou^#, C. Xu^#, L. Dai^#, R. Hou, L. Zheng, C. Fu, G. Shi, J. Wang, Y. Li, J. Cen, X. Xu, L. Yu*, Y. Li*, J. Wang*, Q. Du*, Z. Li*. GRP78 Nanobody-Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy. Advanced Science, 2025, 2408086.

(4) Y. Dong^#, H. Wang^#, Y. Ding, X. Zhang, Y. Zou, Z. Li, S.-C. Zhao, J. Wang*. Croconaine-Based NIR-II Fluorescence Imaging-Guided Tumor Photothermal Therapy Induces Long-Term Antitumor Immune Memory. Journal of Nanobiotechnology, 2024, 22:481.

(5) L. Zheng^#, H. Wang^#, J. Zhou^#, G. Shi, J. Ma, Y. Jiang, Z. Dong, J. Li, Y. He, J. Sun, C. Xu, Z. Li*, J. Wang*. Off-the-Shelf CAR-NK Cells targeting immunogenic cell death marker ERp57 execute robust anti-tumor activity and have a synergistic effect with ICD inducer oxaliplatin. Journal for ImmunoTherapy of Cancer, 2024, 12:e008888.

(6) H. Wang^#, R. Zhou^#, F. Xu^#, K. Yang, L. Zheng, P. Zhao, G. Shi, L. Dai, C. Xu, L. Yu*, Z. Li*, JH. Wang* & JG. Wang*. Beyond canonical PROTAC: biological targeted protein degradation (bioTPD). Biomaterials Research, 2023, 27:72.

(7) H. Wang, H. Bai, J. Wang, X. Zhou, H. Chen, L. Wang, H. Ren, Z. Liu, W. Zhuo, Z. Zhou, J. Tang, Z. Li, J. Wang, Y. Shen, T. Zhou*, X. Liu*. Nanoprodrug ratiometrically integrating autophagy inhibitor and genotoxic agent for treatment of triple-negative breast cancer. Biomaterials, 2022, 283: 121458.

(8) J. Liang^#, HF. Wang^#, W. Ding, J. Huang, X. Zhou, HY. Wang, X. Dong, G. Li, F. Zhou, H. Fan, J. Xia, B. Shen, D. Cai, P. Lan, J. Ling, Z. Cheng*, X. Liu*, J. Sun*. Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity. Science Advances, 2020, 6(35): eabc3646.

科研项目

2025年，国家自然科学基金青年C，在研，主持

2023年，广东省基础与应用基础研究基金联合基金，在研，主持

2022年，中国博士后科学基金面上，结题，主持