个人介绍

熊礼燕，博士，上海大学医学院讲师，研究生专业班导师。2019.4-至今上海大学工作；2015.8-2019.3任中国人民解放军海军军医大学药学院讲师；2014.12-2017.7中国人民解放军海军军医大学药学博士后。主持上海市生物医药科技支撑项目（40万，2021-2024）、横向（100万元，2022.09-2027.09）;参与国家重大新药创制计划、国家自然科学基金、上海市卫计委青年基金、药企委托开发横向课题等4项。近五年，以第一或通讯作者（含并列）在国内外权威期刊上发表SCI论文7篇、授权专利1项。

主要研究领域

1. 中药物质基础及衍生物活性研究；

2. 中药新药的研究与开发：中药Ⅰ类新药“丹参素钠注射液”的临床前研究（临床批文2016L05317）及临床研究（Ⅰ期临床已完成）；抗心肌缺血再灌注损伤口服丹参素类药物的临床前研究；排石颗粒临床前研究；

代表性学术成果

论文

1. Dan Jia^#, Liyan Xiong^#, Xuhong Yu, Xiaofei Chen, Tingfang Wang, Alex F. Chen, Yifeng Chai, Zhenyu Zhu* and Chuan Zhang*. Cardioprotective mechanism study of salvianic acid A sodium based on a proteome microarray approach and metabolomic profiling of rat serum after myocardial infarction. Molecular Omics, 2019,15(4):271-279.

2. Liyan Xiong^#, Jing Wang^#, Tingfang Wang, Chuan Zhang*. Quantitative determination of Sodium Danshensu in Beagle Dog Plasma by HPLC-MS/MS and its Application to a Preclinical Toxicokinetics Study. Lat. Am. J. Pharm. 2020,39(5): 897-903.

3. Hao Shi^#, Liyan Xiong^#, Chenchen Zhu, Jing Wang, Yi Li, Yunchun Luo, Tingfang Wang*, Chuan Zhang*. Design, Synthesis, and Biological Evaluation of Novel NO-Releasing 4-chromanone Derivatives as Potential Vasodilatory Agents. Chemical Biology & Drug Design

4. JunLiao^#, YiLi^#, Yunchun Luo, Sha Meng, Chuan Zhang, LiyanXiong*, TingfangWang*, YingLu*. Recent Advances in Targeted Nanotherapies for Ischemic Stroke. Molecular Pharmaceutics，2022,19(9):3026-3041

5. Yan Zhang^#, Yuzhen Feng, Mei Zhang, Deliang Kong*, Liyan Xiong*, Qinqin Yang*. Preliminary study on the improvement of identifying efect of Tc‑99 m labeled C595 monoclonal antibody in MUC1 imaging of ovarian cancer. Journal of Radioanalytical and Nuclear Chemistry ，2022，331:4189–4195.

6. Danni Li^# , Liyan Xiong^#, Guixia Pan, Tingfang Wang, Rou Li, Lizhi Zhu, Qianqian Tong, Qinqin Yang, Ye Peng, Changjing Zuo*, Cong Wang*, Xiao Li*. Molecular Imaging on ACE2-dependent Transocular Infection of Coronavirus. Journal of Medical Virology. 2022,94(10):4878-4889.

7. Yi Li^#, Yunchun Luo^#, Jing Wang^#, Hao Shi, Jun Liao, Yan Wang, Zhesheng Chen, Liyan Xiong*, Chuan Zhang*, Tingfang Wang*. Discovery of novel danshensu derivatives bearing pyrazolone moiety as potential anti-ischemic stroke agents with antioxidant activity. Bioorganic Chemistry, 2022,131:106283.

参编著作

《中国药用植物志》第九卷，北京大学出版社，2017年，参编。