个人介绍

董霄，副教授，硕士研究生导师，上海市海外高层次人才, 上海市第十三届青年联合会委员（教育界别），中国医药生物技术协会精准医疗分会委员。2019年6月毕业于上海交通大学医学院药学专业，获博士学位（导师：方超教授）。2019年8月至2021年8月在新加坡国立大学从事科学研究，任Research Fellow（合作导师：Prof Yao Shao Qin）。2022年1月加入上海大学医学院，从事基于纳米递药系统的肿瘤治疗新策略与新技术研究。主持国家自然科学基金青年基金，上海市科委国际合作项目，上海市科委扬帆计划以及多项企业横向课题。曾获2023年度上海药学科技二等奖（5/10），2024年度第七届全国药学专业学位优秀教学案例奖（3/3），上海市优秀毕业生（2019），上海交通大学优秀博士毕业生发展奖学金（2020）。目前以第一作者或通讯作者在Adv. Mater.，Angew. Chem. Int. Ed. Engl.，ACS Cent. Sci.，Adv. Funct. Mater.，Biomaterials，Nano Lett.等国际期刊上发表论文10余篇，累计参与发表SCI论文20余篇，申请发明专利3项。担任Pharmaceutics（IF 5.4）杂志客座编辑以及Advanced Science、Journal of Controlled Release、Advanced Composites and Hybrid Materials、Journal of Nanobiotechnology等杂志审稿人。

主要研究方向

1. 基于纳米递送载体的肿瘤免疫调控策略与关键技术

2. 用于增强肿瘤免疫治疗的mRNA纳米药物及递送系统开发

代表性论文（#共同第一作者或*通讯作者）

1. X. Wang,# C. Liu,# R. Ji, J. Liu, Y. Shao, S. Xia, J. Li, X. Zhang, L. Luo, Y. Wu, S. Yao, C. Fang,* L. Chen,* and X. Dong* Lipid Droplet-Targeted Biomimetic Liposomes Potentiate Chemo-Ferroptosis Therapy in Leukemia, Adv Mater, 2026, 38, e15716.

2. S. Xia,# X. Wang,# C. Liu, R. Ji, M. Wang, C. Zhang, L. Chen, W. Chen,* S. Yao, C. Fang* and X. Dong* Hypochlorous Acid-Responsive Prodrug Nanoplatform for Synergistic Cancer Immunotherapy, Biomater Res, 2026, 30, 0300.

3. C. Liu,# X. Wang,# M. Wang, R. Ji, S. Xia, L. Chen, S. Yao, Z. Gu*, C. Fang* and X. Dong* Multifunctional Nanoagonist Enhances Photodynamic Therapy-Driven In Situ Cancer Vaccination by Inhibiting Tumor Thrombosis, J Nanobiotechnology, 2025, 23, 274.

4. J. Sun, # L. Lou,# C. Zhu,# P. Chen, G. Tang, M. Gu, S. Xia, X. Dong,* Z. Zhang,* L. Gao,* S.Q. Yao,* Chemical Evolution to Improve Bcr-Abl Kinase Inhibitors via Covalent and Pro-/Dual-drug Targeting Strategies, J. Adv. Res. 2025, 74, 541-545.

5. D. Xia,# Q. Qian,# S. Wang,# X. Dong,* Y. Liu,* Alendronate Functionalized Bone-Targeting Pomolic Acid Liposomes Restore Bone Homeostasis for Osteoporosis Treatment, Int J Nanomedicine. 2024, 19, 7983-7996.

6. X Dong,*# S Xia,# SB Du, MH Zhu, X Lai, SQ Yao, HZ Chen, C Fang.* Tumor Metabolism-Rewriting Nanomedicines for Cancer Immunotherapy, ACS Cent. Sci. 2023, 9, 10, 1864-1893.

7. W Du,# SB Du,# X Dong,# H Bai, JM Jiang, SP Hao, F Yang, QC Xiao, B Zhang, JY Ge, LQ Gao, L Li,* SQ Yao,* W Huang,* Biodegradable silica nanocapsules enable efficient nuclear-targeted delivery of native proteins for cancer therapy, Biomaterials, 2023, 294, 122000.

8. X Dong,* RK. Brahma, C Fang, SQ Yao,* Stimulus-Responsive Self-Assembled Prodrugs in Cancer Therapy. Chem. Sci., 2022, 13, 4239-4269.

9. SY Ong,# CY Zhang,# X Dong,* SQ Yao,* Recent Advances of Polymeric Nanoparticles for Enhanced Fluorescence and Photoacoustic Imaging. Angew. Chem. Int. Ed. Engl. 2021, 133, 17941-17953.

10. X Dong, SY Ong, CY Zhang, WQ Chen, QC Xiao, LQ Gao, SQ Yao,* Broad-Spectrum Polymeric Nanoquencher as An Efficient Fluorescence Sensing Platform for Biomolecular Detection. ACS Sens. 2021, 6, 8, 3102-3111.

11. X Dong,# LL Mu,# XL Liu, H Zhu, SC Yang, X Lai, HJ Liu, HY Feng, Q Lu, BB Zhou, HZ Chen, GQ Chen, JF Lovell, DL Hong,* C Fang,* Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co‐Targeting of Therapy‐Induced Bone Marrow Niches. Adv. Funct. Mater. 2020, 30, 2000309.

12. X Dong, HJ Liu, HY Feng, SC Yang, XL Liu, X Lai, Q Lu, JF Lovell, HZ Chen, C Fang,* Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor to Induce Tumor Collagen Depletion. Nano Lett. 2019, 19, 997-1008.

社会任职

上海市第十三届青年联合会委员（教育界别），中国医药生物技术协会精准医疗分会委员，Pharmaceutics（IF5.4）杂志客座编辑。