个人介绍

董昕，副教授，主要研究方向是基于质谱平台的代谢组学及蛋白质组学新方法开发及应用，近年来主要应用组学方法针对大型人群的健康管理及疾病预防，进行新型生物标志物筛选及机制研究。现任中华医学会骨科学分会青年委员会骨质疏松学组委员，上海市中西医结合学会骨质疏松专业委员会常务委员，中国老年学和老年医学学会老年病分会骨科专家委员会常务委员。担任 Journal of Pharmaceutical and Biomedical Analysis，Journal of Chromatography B，scientific reports等国际药物分析专业期刊的特邀审稿人。作为负责人主持国家自然科学基金、上海市自然科学基金、上海市科委生物医药支撑项目、军委科技委国防科技创新特区主题项目等多项科研项目，科研经费近500万元。获上海市中西医结合一等奖一项。近五年作为第一或通讯作者发表SCI论文30余篇。

主要研究领域

基于质谱平台的代谢组学及蛋白质组学新方法开发及应用，应用组学方法针对大型人群的健康管理及疾病预防，进行新型生物标志物筛选及机制研究

代表性学术成果

论文

1. Songyan Gao^#, Rui Yang^#, Zhongjiang Peng, Hongtao Lu, Na Li, Jiarong Ding, Xingang Cui, Wei Chen*, Xin Dong*.Metabolomics analysis for hydroxyl-L-proline-induced calcium oxalate nephrolithiasis in rats base on ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry. Sci. Rep. 2016 Jul 22;6:30142.

2. Li Su^#, Hongxia Zhao^#, Xiuhua Zhang, Ziyang Lou*, Xin Dong*. UHPLC-Q-TOF-MS based serum metabonomics revealed the metabolic perturbations of ischemic stroke and the protective effect of RKIP in rat models. Mol. BioSyst.,2016,12,1831.

3. Hongxia Zhao ^#, Hongli Du ^#,Min Liu^#, Songyan Gao, Na Li, Yufan Chao，Ruiqing Li，Wei Chen*，Ziyang Lou*，Xin Dong*. Integrative Proteomics−Metabolomics Strategy for Pathological Mechanism of Vascular Depression Mouse Model. Journal of Proteome Research. 2018 Jan 5;17(1):656-669.

4. Li Su ^#, Na Li^#, Hua Tang, Ziyang Lou, Xiaodan Chong, Chenxi Zhang, Jiacan Su*, Xin Dong*. Kupffer cell-derived TNF-α promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells. Cell Death &Disease.2018 02 23;9(3).

5. Chao Yufan^#, Gao Songyan^#, Wang Xuelei^#, Li Na, Zhao Hongxia, Wen Xiaofei^*, Lou Ziyang^*, Dong Xin^*. Untargeted lipidomics based on UPLC-QTOF-MS/MS and structural characterization reveals dramatic compositional changes in serum and renal lipids in mice with glyoxylate-induced nephrolithiasis. Journal of Chromatography B.  2018 Sep 15;1095:258-266. doi: 10.1016/j.jchromb.2018.08.003

社会学术兼职

中华医学会骨科学分会青年委员会骨质疏松学组委员

上海市中西医结合学会骨质疏松专业委员会常务委员

中国老年学和老年医学学会老年病学分会骨科（上海）专家委员会常务委员