个人介绍：

罗凌杰，上海大学医学院副研究员。获西安交通大学临床医学学士学位，巴黎第十一大学免疫学硕士学位，巴黎第七大学免疫学博士学位，曾任巴黎巴斯德研究所Research Fellow。2017年回国后在上海交通大学医学院上海市免疫学研究所先后担任助理研究员、副研究员，于2024年1月加入上海大学医学院。主要从事抗原识别和应用及免疫调控机制研究，主持了国家自然科学基金青年基金项目，上海市卫健委项目，并作为骨干参与科技部重点研发计划青年科学家项目。以第一作者（含共一）在PNAS，Cell Discovery上发表多篇SCI论文，申请发明专利一项。

主要研究领域：

1.抗原识别与免疫治疗

2.免疫调控机制研究

代表性学术成果：

论文（最具代表性）

1.Targeting early EBV-driven IDO1-NAD metabolism as a potential therapeutic strategy for EBV-related diseases. Lingjie Luo^#, Pei Xuying^#, Zhang Chunli^#, Chen Liang^* and Mo Xiaodong^*. The Innovation Medicine 2(3): 100084.

2.Identification and affinity enhancement of T-cell receptor targeting a KRAS^G12V cancer neoantigen. Mengyu Zhang^#, Wei Xu^#, Lingjie Luo^#, Fenghui Guan, Xiangyao Wang, Pei Zhu, Jianghua Zhang, Xuyu Zhou^*, Feng Wang^* and Sheng Ye^*. Commun Biol. 2024 Apr;7(1): 512.

3.Characterizing the cellular and molecular variabilities of peripheral immune cells in healthy recipients of BBIBP-CorV inactivated SARS-CoV-2 vaccine by single-cell RNA sequencing. Rengyang Tong^#, Lingjie Luo^#, Yichao Zhao^#, Mingze Sun^#, Ronghong Li, Jianmei Zhong, Yifang Chen, Liuhua Hu, Zheng Li, Jianfeng Shi, Yuyan Lyu, Li Hu, Xiao Guo, Qi Liu, Tian Shuang, Chenjie Zhang, Ancai Yuan, Lingyue Sun, Zheng Zhang, Kun Qian, Lei Chen, Wei Lin, Alex F chen, Feng Wang^* and Jun Pu^*. Emerg Microbes Infect. 2023 Dec;12(1): e2187245.

4.Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Lingjie Luo^#, Wenhua Liang^#, Jianfeng Pang^#, Gang Xu^#, Yingying Chen^#, Xinrong Guo, Xin Wang, Yi Zhao, Yangdian Lai, Yang Liu, Bin Li, Bing Su, Shuye Zhang, Michal Baniyash, Lei Shen, Lei Chen, Yun Ling, Ying Wang, Qiming Liang, Hongzhou Lu^*, Zheng Zhang^* and Feng Wang^*. Cell Discovery. 2021 Sep 28;7(1): 89

5.Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade. Shan Sun^#, Lingjie Luo^#, Wenhua Liang^#, Qian Yin, Jing Guo, Anthony M. Rush, Zhibao Lv, Qiming Liang, Michael A. Fischbach, Justin L. Sonnenburg, Dylan Dodd, Mark M. Davis^*, and Feng Wang^*. Proc Natl Acad Sci USA. 2020 Nov 3;117(44): 27509-27515.

6.Essential role of immobilized CXCL12 in the regulation of the humoral immune response. Aleksandr Barinov^#, Lingjie Luo^#, Pamela Gasse^#, Vannary Meas-Yedid Hardy, Emmanuel Donnadieu, Fernando Arenzana-Seisdedos^* and Paulo Vieira^*. Proc Natl Acad Sci USA. 2017 Feb 28;114(9): 2319-2324.

7.Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains. Yoan R Monneau^#, Lingjie LUO^#, Nehru Viji SANKARANARAYANAN, Balaji NAGARAJAN, Romain Vivès, Françoise Baleux, Fernando Arenzana-Seisdedos^* and Hugues Lorata-Jacob^*. Open Biol. 2017 Oct 1; 7(10) 170133.

^#共同第一作者

*共同通讯作者