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刘天琪

创建时间:  2020-06-24  孙湛蓉   浏览次数:   返回

个人介绍

刘天琪,2019年毕业于北京协和医学院-清华大学医学部,获得医学博士学位,同年入职上海大学医学院任讲师。代表性论文发表在Bioorganic Chemistry、The Journal of Organic Chemistry、Journal of Chemical Information and Modeling、RSC Advances等期刊上。


主要研究领域

主要从事药物化学、有机合成方法学等方面的研究,运用计算机辅助药物分子设计方法,基于多样性导向合成策略,构建结构多样的小分子化合物库,开发新型有效的心血管疾病治疗药物。


代表性学术成果

论文

1. Liu T, Jin J, Chen Y, Xi Q, Hu J, Jia W, Chen X, Li Y, Wang X*, Yin D. Identification and Structure–Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P1). Bioorg. Chem., 2019, 82, 41-57.

2. Liu T, Jia W, Xi Q, Chen Y, Wang X*, Yin D. Diversity-Oriented Synthesis of Heterocycles: Al(OTf)3-Promoted Cascade Cyclization and Ionic Hydrogenation. J. Org. Chem., 2018, 83 (3), 1387-1393.

3. Liu T, Wang X*, Yin D*. Recent progress towards ionic hydrogenation: Lewis acid catalyzed hydrogenation using organosilanes as donors of hydride ions. RSC Adv., 2015, 5 (92), 75794-75805.

4. Chen Y, Liu T, Xi Q, Jia W, Yin D, Wang X*. A Computational Approach to the Study of the Binding Mode of S1P1R Agonists Based on the Active-Like Receptor Model. J. Chem. Inf. Model., 2019, 59 (4), 1624–1633.

5. Jia W, Xi Q, Liu T, Yang M, Chen Y, Yin D, Wang X*. One-Pot Synthesis of O-Heterocycles or Aryl Ketones Using an InCl3/Et3SiH System by Switching the Solvent. J. Org. Chem., 2019, 84, 5141-5149.

6. Ge J, Wang X*, Liu T, Shi Z, Xiao Q, Yin D*. Assembly of substituted phenanthridines via a cascade palladium-catalyzed coupling reaction, deprotection and intramolecular cyclization. RSC Adv., 2016, 6 (23), 19571-19575.

7. Fang L, Wang X*, Xi M, Liu T, Yin D*. Assessing the ligand selectivity of sphingosine kinases using molecular dynamics and MM-PBSA binding free energy calculations. Mol. Biosyst., 2016, 12 (4), 1174-1182.






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